Symptoms of acute toe osteomyelitis include stagnant proliferation of bacteria in the long bone epiphysis, causing a bacterial inflammatory reaction that manifests as local tissue redness, swelling, heat, and pain, as well as skin redness, soft tissue swelling, and increased skin temperature with distension. Abscesses can form after 3-5 days of onset and can be palpable and volatile. It can also cause systemic symptoms, such as high fever and chills due to endotoxin secretion by the bacteria, as well as severe bacterial infections, which can even lead to central nervous system symptoms. Osteomyelitis of the toe requires early treatment. Primary osteomyelitis should be treated with sensitive antibiotics as soon as possible, and if the condition improves within 3 days, treatment can be continued. If the condition does not improve or worsens within 3 days, then surgical treatment is recommended as an option to control the infection by opening a window in the infected area to reduce pressure and drain the pus. In case of secondary osteomyelitis, mostly caused by open fractures, it is recommended to choose direct surgery to remove the dead bone and infected tissue.