The treatment of toe osteomyelitis mainly includes conservative treatment and surgical treatment. In acute osteomyelitis of the toe caused by trauma or surgery, attention should be paid to reducing the activity of the affected limb by braking. Conservative treatment with targeted antibiotics, mainly penicillins or cephalosporins that are sensitive to Staphylococcus aureus or Streptococcus haemolyticus, should also be administered intravenously. For example, ampicillin and cefuroxime. If necessary, treatment can be combined with anti-anaerobic drugs, such as metronidazole, and local topical treatment with Chinese herbs can also be used at the same time. If there is obvious local abscess formation, surgical incision and drainage is required, and attention should be paid to regular drug changes to help control the inflammation. If the above conservative treatment does not work well, surgical amputation of the toe should be considered.