Indications: 1, degenerative knee osteoarthritis (OA): Aged knee OA accounts for 70-80% of total knee replacements. 2, rheumatoid arthritis (RA) and ankylosing spondylitis (AS) of the knee joint advanced lesions: RA or AS can often involve bilateral knee, joint. 3, other non-infectious arthritis caused by knee joint lesions with pain and dysfunction. Such as large osteoarthrosis, hemophilic arthritis, etc. 4, traumatic osteoarthritis: osteoarthritis after severe trauma involving the joint surface, such as cases where the joint surface fails to repair after a comminuted plateau fracture and seriously affects function, as well as secondary osteoarthritis due to meniscal injury or after resection. 5, cases with large osteochondral necrosis or other lesions of the knee joint that cannot be repaired by conventional surgical methods. 6.Joint destruction following infectious arthritis can be a relative indication for TKA if no active infection is confirmed. 7, Cases in which good joint function reconstruction cannot be obtained after resection of tumors involving the knee joint surface. For example, in cases of bone tumors of the distal femur or proximal tibia, if the limb can be preserved, artificial knee arthroplasty with special prosthesis can be performed after resection of the tumor segment. Contraindications: 1, muscle paralysis around the knee joint, or muscle weakness due to neurological diseases; 2, acute or chronic infectious diseases, active tuberculosis infection, bleeding diseases; 3, the knee joint has been fused in a functional position for a long time without symptoms such as pain and deformity; 4, severe osteoporosis, joint instability, severe muscle weakness, fibrous or bony fusion is not an absolute contraindication to surgery.