Naproxen and ibuprofen are both non-steroidal antipyretic and analgesic drugs. Although the mechanism of action, efficacy and side effects of the two drugs are the same, there are some differences in drug metabolism time and clinical application. 1, the same 1, mechanism of action: these two drugs are non-steroidal aromatic propionic acid analgesics, are through the inhibition of cyclooxygenase, inhibit the synthesis of prostaglandins, and play the effect of antipyretic, analgesic, anti-inflammatory; 2, efficacy: both drugs can be used for rheumatic and rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, tenosynovitis and other diseases, can also be used for bone sprains, contusions and dysmenorrhea caused by It can also be used for pain caused by bone sprains, contusions and dysmenorrhea, and for reducing fever; 3. Side effects: mainly seen in the gastrointestinal tract reactions, manifested as stomach pain, nausea, vomiting, abdominal pain, diarrhea, serious peptic ulcer and gastrointestinal bleeding, some patients will also have water and sodium retention, increased blood pressure and liver and kidney damage. The half-life of ibuprofen is shorter, 1.8-2 hours, and needs to be given several times a day, while naproxen has a long half-life of 13-14 hours, with longer lasting effects and fewer doses in a day; 2. It is often used to reduce fever and mild to moderate pain caused by various reasons. Naproxen has less clinical application and is basically not used to relieve fever and analgesia, and is mainly used to treat rheumatic and rheumatoid arthritis.