AMH, anti-mullerian hormone, is a biomarker that has stood out in recent years, secreted by granulosa cells of small sinus follicles, reflecting ovarian reserve function and predicting responsiveness to ovarian stimulation. In IVF treatment, ovarian reserve function is one of the key factors in determining whether a satisfactory outcome can be achieved. AMH has become a valuable predictor after age and sinus follicle count (AFC). When designing an ovulation protocol for a patient, clinicians usually refer to the woman’s age, basal FSH value, body mass index (BMI), and sinus follicle count (AFC) to determine the initiation dose of ovulation-promoting drugs. Now with AMH as a reference to guide the dose of medication, the safety and efficacy of ovulation promotion has been effectively improved. In a retrospective study in the UK, comparing a study group with an AMH-based stimulation regimen to a control group with a basal FSH-based regimen, it was found that the incidence of OHSS and cycle cancellation rates decreased in the AMH group compared to the FSH group, and pregnancy and live birth rates increased significantly, while reducing the financial burden on patients. Some studies have shown a positive correlation between AMH and fertilization rate, embryo implantation rate, clinical pregnancy rate and live birth rate, but this finding is controversial. It has also been shown that AMH correlates less with clinical pregnancy rates in women with normal ovarian reserve, but more significantly in women with low ovarian reserve. Therefore whether AMH reflects the quality of oocytes and the relationship with pregnancy outcome still needs to be validated from multiple perspectives. AMH represents the number of eggs, but not their quality; a high AMH value only represents the number of eggs, not their quality, which is related to age. For example, if the AMH value is low, but the patient is young and has good quality eggs, she will have a chance to get pregnant even if the number of eggs is low; if she is older, the quality of her eggs will be poor, and even if the AMH value is good, the pregnancy rate will still be affected! Advantages of AMH in predicting ovarian function AMH has the following advantages compared to other methods of predicting ovarian function: 1. As age increases, ovarian function gradually declines and so does the AMH value. Therefore, of all the methods used to detect ovarian function, AMH values are the earliest to screen for ovarian failure. 2. The concentration of AMH is not affected by the menstrual cycle, so the concentration of blood drawn during any period is equally stable. 3. AMH screening in young women can detect early ovarian failure, so that women can be treated in real time to avoid wasting time and waiting until it is too late to plan for a baby. The above studies show that AMH is an important indicator to predict ovarian function. AMH test first! Even if you are still young, if you find that your AMH is too low and your ovaries are close to 40 years old, do you want to take your time? So no matter how old you are, AMH is measured first!