Mr. Li is 45 years old and has an enviable career as a director of a foreign enterprise, earning a good income, but he is always on the go and very busy. He almost never goes to the hospital to see a doctor, even for routine medical checkups arranged by the company, because he thinks it is useless and a waste of time. In his own words, “the time to queue up for medical check-ups at the hospital, I can create a few substantial profits for the company.” In early July 2006, Mr. Li gradually felt weakness in his legs during his intense and busy work, his feet were as heavy as lead, and his urine was no longer as smooth as before, but required a forceful burst of air to be lifted. Mrs. advised him to go to the hospital as soon as possible, but he thought it was due to overexertion, rest for two days will be fine. A week passed, and on this day there was an important business that required him to fly out of town to deal with, so Mr. Li reluctantly dragged his heavy legs to the airport. However, when he was about to get on the plane, he suddenly felt that he could not move his legs, and was immediately taken to the hospital by his colleagues for treatment. It was found that Mr. Li was suffering from acute spinal cord compression syndrome caused by metastatic bone tumor, which has lost the best treatment time and paraplegia is inevitable. …… This is what is usually called bone adverse event in clinical practice, which refers to skeleton-related complications caused by various reasons, including pathological fracture, bone fracture, dislocation, paraplegia, secondary infection, etc. Metastatic bone tumor is what we usually call metastatic bone cancer, which has a very high incidence, far exceeding that of primary bone tumor, 40 times more than the incidence of primary bone tumor, and can be caused by metastasis of various malignant tumors. It can be caused by many kinds of malignant tumors, such as lung cancer, breast cancer, prostate cancer, nasopharyngeal cancer, etc. In addition, about 30% of patients with metastatic bone cancer cannot find the primary lesion. According to a conservative estimate, among the existing malignant tumor patients in Shanghai, there are as many as 35,000 patients who have had or will have bone metastasis, and the follow-up, diagnosis and treatment of these patients should be given sufficient attention. Metastatic bone tumors tend to occur in bones with rich blood supply, such as the spine, and if they are not detected in time or treatment is delayed, they will often bring serious complications to patients. In Mr. Li’s case, metastatic adenocarcinoma in the lumbar spine was not treated in time and caused permanent damage to the spinal cord, resulting in paraplegia and regret. Some metastatic bone tumors in the thoracic spine or even the cervical spine are even more dangerous and often lead to paraplegia or even endanger the life of the patient. Therefore, early detection, early diagnosis and early treatment of metastatic bone tumors are of great importance. Once the spinal cord is compressed for more than 72 hours, irreversible damage will be formed, and in the week before that, patients often have numbness, weakness, heaviness of the limbs, difficulty in defecation and other preliminary symptoms, which is the best time for treatment. Through dehydration treatment, interventional treatment (vertebroplasty), internal fixation of vertebral body and spinal cord decompression, external radiation therapy, internal radiation therapy and other measures to control the development of local tumor and compression symptoms, together with active anti-tumor treatment, most patients can obtain remission and avoid the serious complications of paraplegia. Then, will all people with the above manifestations have metastatic bone cancer? Of course not. However, it is very important to face it positively and seriously, especially those with high incidence of metastatic bone tumor, some of them are patients who have had malignant tumors such as lung cancer, breast cancer, prostate cancer and head and neck cancer in the past and have been cured after treatment, and these people may still have bone metastasis in the future; secondly, those who are current cancer patients, they are either receiving anti-tumor treatment or their condition is in These patients have a higher chance of bone metastasis; the third situation is the occult patients with malignant tumors, who have metastatic bone tumors as the first symptom, similar to Mr. Li’s development. The above groups should receive special examinations related to bone metastasis regularly. Some of the commonly used clinical examinations are: whole-body bone imaging with radioisotopes, X-ray, CT or MRI of bones, detection of serum alkaline phosphatase and tumor markers, PET examination, etc. For the above high-risk groups, it is recommended that reasonable examinations should be targeted every 3 to 6 months to assess whether there are bone metastases or bone metastases in order to provide timely treatment and effectively prevent adverse bone events.