The early and late stage of breast cancer is related to the size of the lump, but a large lump does not mean advanced stage. Generally speaking, late stage refers to distant metastasis, such as lymph node metastasis, bone metastasis, soft tissue metastasis, and even organ metastasis, including brain metastasis, lung metastasis and liver metastasis, which is distant metastasis, that is, advanced stage; large local lump refers to the diameter of the primary tumor, large lump but no other distant metastasis, we do not call it advanced stage, but also called early stage. For early stage cancer with a large local mass but no metastasis, if surgery is done directly, the surgical invasion is relatively large and it is not easy to do breast conservation. In the treatment of such patients, neoadjuvant chemotherapy or neoadjuvant targeted therapy will be used before surgery to reduce the size of the lump for surgical treatment; in addition, some patients have large lumps and distant metastases.