Rheumatic diseases are related to autoimmunity and often lead to the involvement of multiple systems and organs throughout the body, as follows: 1. mucosal involvement of the skin throughout the body: various rashes, such as herpes, rashes, papules, etc., and also mucosal ulcers or erosions; 2. heart involvement: arrhythmia or heart failure, and even life-threatening; 3. kidney involvement: hematuria, proteinuria or renal failure; 4. The most common is interstitial lung changes, which can lead to interstitial lung fibrosis and even combined pulmonary hypertension, which can be life-threatening; 5. Central nervous system involvement: leading to personality changes, mental disorders, seizures, and even coma, etc., and also various cerebrovascular accidents.