1. Where patients feel inconvenienced “swollen feet, shoes don’t fit” “numb feet, difficulty walking” “high heels don’t fit” etc. 2. Causes Capecitabine (Xyroda) and some molecular Hand-foot syndrome”, a side effect caused by capecitabine (Xyroda) and some molecular targeting drugs, appears 2 to 4 weeks after the drug is administered and causes symptoms such as edema, skin cracking and pain on the palms of the hands and soles of the feet. Walking may become difficult when plantar discomfort worsens. Chemotherapy drugs cause peripheral nerve damage, which can lead to numbness in the hands and feet. It takes time to gradually recover after chemotherapy is finished and in some cases it is difficult to return to full normal. Tissue swelling and lymphatic swelling caused by the side effects of the drugs cause numbness of the soles of the feet is also often seen. 3.Life care 1）Choose shoes with non-slip soles and fall easily when the feet are numb or edematous. (2) Avoid pinching your feet and choose large size shoes. To protect your skin, it is recommended to wear soft, loose and thick socks. When “hand-foot syndrome” occurs, it is best to wear flat shoes and avoid high-heeled shoes in order to distribute the weight on the bottom of the foot. 4) Numbness of the foot will be reduced after exercise and warmth. 5) When the foot is swollen, take care to prevent damage to the skin of the foot. Elevate the lower limb during rest to reduce edema. When lymphatic swelling is present, give lymphatic massage to prevent swelling from getting worse.