Breast cancer is one of the malignant tumors that are most prone to bone metastasis, that is, breast cancer is prone to bone metastasis during the course of the disease. Bone metastasis mainly manifests as pain, pain in the long bones of the limbs or back pain, and in severe cases, fracture of the weight-bearing bones, which may lead to paraplegia, incontinence and numbness of both lower limbs. The main prevention of bone metastasis is: 1) the use of anti-metastatic drugs such as zoledronic acid; 2) the strengthening of the treatment of the original disease, such as the use of chemotherapy drugs for breast cancer to prevent recurrence after surgery, and if the hormone receptor-positive breast cancer, targeted drugs can be used for maintenance, especially endocrine drugs for maintenance.