The diagnosis of adverse building syndrome can be made on the basis of signs and symptoms. The eight main manifestations of building syndrome identified by the World Health Organization are: irritation of the eyes, especially the cornea, nasal mucosa and laryngeal mucosa. Dryness of the lips and other mucous membranes. Frequent skin erythema, urticaria, eczema, etc. Fatigue easily. Headache and respiratory tract infections. These signs can be used as a basis for diagnosis. In addition, the diagnosis of dysphoric building syndrome is based on the clinical presentation of the patient, onset in a group of colleagues, improvement of symptoms after leaving the building, absence of pathophysiologic abnormalities and absence of any etiologic similarities. Adverse building syndrome is not a specific diagnosis and it is not necessary to exclude all other possibilities before taking measures to solve it. The diagnosis must be made with attention to the patient’s symptoms, occupational history and environmental circumstances including working hours and home environment. The main features are: basic personal information; symptomatology; description of the work process and indoor environment, ventilation, exposure sources, dust, humidity, temperature and light; whether there are any changes in the environment such as new renovations, new equipment, or other relevant changes; colleagues with the same symptoms and symptoms that can improve after leaving the building are quite important for the diagnosis of good building syndrome; some other factors should also be included Other factors such as job satisfaction, job stress, etc.