Systemic lupus erythematosus (SLE) is a specific autoimmune disease with multifactorial involvement. Patients are characterized by multiple autoantibodies (the most important of which are double-stranded DNA antibodies), and almost every system and organ in the body may be involved through immune complexes. SLE is more common in young women, with 90% to 95% of women of childbearing age, and the disease is prolonged and recurrent, but proper treatment and self-protection can achieve better results. Environmental factors play an important role in the occurrence and development of the disease. Such as infection, dietary factors, toxins or drugs, physical or chemical factors can cause inflammation, induce apoptosis, cause tissue damage, so that SLE relapse and remission alternately, and the occurrence and development of SLE, must be added to prevent. Ultraviolet light is an important trigger for many SLE patients. UV light can alter the chemical structure of DNA in skin tissues and increase their immunity. Recent studies have also found that UV light induces apoptosis in human skin keratinocytes, resulting in the formation of clusters or vesicles on the surface of apoptotic cells containing nuclei and cytoplasmic antigens, which provides a basis for the exposure of autoantigens to the immune system and promotes autoimmune responses. Therefore, all SLE patients must pay attention to avoid UV radiation, and when going out (especially in summer) must do a good job of UV protection to avoid aggravating the disease. When outdoors, you can apply 3% quinine ointment on the face, wear long-sleeved clothing and wide-brimmed hats to reduce sunlight exposure to avoid aggravation of skin lesions. There should be curtains indoors to avoid ultraviolet radiation. In addition, many chemical or physical factors have the effect of triggering or aggravating SLE. Many aromatic amines, hydrazines (e.g., procaine, hydrazinepyridazine) and other drugs (chlorpromazine, isoniazid, phenytoin and penicillamine) can trigger lupus-like syndrome, especially in individuals with slow reactions to acetylation. Aromatic amines, hydrazine compounds and their derivatives are used in large quantities in industry, agriculture and daily life. Hydrazines can also be produced in tobacco and cigarettes, and patients with lupus-like syndrome have been associated with the ingestion of or exposure to these substances. Aromatic amines contained in colored hair dyes can be absorbed into the scalp, and long-term use of hair dyes can lead to SLE; however, there are studies that do not support this claim, and recent research suggests only a weak association between SLE and continued hair coloring and smoking. However, it is best to use caution. The role of estrogen in the diet and environment for SLE patients should not be overlooked. With the high consumption of meat and dairy products from synthetic hormone-fed livestock, human exposure to environmental estrogens is increasing. At the same time, the use of estrogens in menopausal women and contraceptives is also increasing. Prolonged exposure to estrogens in adolescent non-immune mice can affect thymus development and lead to immune tolerance. Fetal exposure to estrogenic compounds appears to be a potential immune risk factor, and prenatal exposure to diethylstilbestrol has been found to be strongly associated with autoimmune disease. Environmental estrogens and endocrine structural disruption are important triggers for individual susceptibility to autoimmune disease, but the eventual development of SLE requires the involvement of multiple factors such as genetic background, gender, age, dose and duration of antigen exposure, and immune status at the time of antigen exposure. Therefore, attention should be paid to all patients with SLE. According to the theory of Chinese medicine, SLE is caused by the invasion of fire and heat into the body’s blood and blood, whether it is ultraviolet radiation, or spicy, dry and other hot foods are conducive to the role of heat and fire, and must be avoided. Especially in the hot summer, should try to reduce or avoid the influence of such adverse factors. Although some herbal teas from all over Guangdong have the effect of clearing away heat and fire, they are not suitable for everyone, and it is best to take them under the guidance of an experienced doctor, otherwise they are not conducive to the control of the disease.