A fracture is a bone damage that occurs when the external force to the body exceeds the limit of bone tolerance. After a fracture, a series of local and systemic reactions are induced, and the clinical procedure is carried out according to the location and degree of fracture damage, and the relevant medication is used to treat the complications. So how to choose the right medication for treatment? A, the treatment of infection drugs fracture and postoperative easy to complicate local and systemic infection, the choice of antibiotics we should avoid the use of these antibiotics: 1, aminoglycosides one of the main toxic side effects of this class of drugs is similar to arrow poison blocking acetylcholine and complex calcium ion effect. Calcium ion is one of the necessary metal ions for fracture healing, and complexed calcium is difficult to be absorbed and used by the tissue, which is not conducive to fracture healing. 2, tetracycline class of drugs can be complexed with many metal ions, such as calcium, magnesium, aluminum, iron (including herbs containing these ions such as keel, natural copper, etc.), weakening the therapeutic role of these ions in fracture healing; at the same time, tetracycline class of drugs can be permanently bound into the calcified tissue, which can cause growth retardation of animal and human embryonic bones, and cause epiphysis and epiphyseal parts of the bone trabeculae It can also cause deformation and even fracture of bone trabeculae in the epiphysis and epiphysis, which is not good for fracture healing. 3. Quinolones are widely used for the treatment of various infections in recent years, and these drugs have an effect on the development of cartilage, so pregnant women and underage children should use this product with caution. The formation of bone scab in fracture healing requires the formation of new bone within the cartilage ossification, quinolones affect the development of cartilage, and therefore affect the process of cartilage maturation required for the formation of bone scab, so this class of drugs should be used with caution in the treatment of fractures complicated by infection. Second, the treatment of shock extensive fracture injury is prone to complications of infectious and hemorrhagic shock. Glucocorticoids are often considered in anti-infective and anti-shock treatment, and this class of drugs has stable and reliable clinical efficacy in anti-inflammatory and anti-shock treatment. However, long-term or high-dose use of glucocorticoids can cause side effects such as osteoporosis, decalcification, pathological fractures, and poor wound healing, which interfere with the physiological process of fracture healing. Therefore, the use of glucocorticoids in the treatment of infectious and hemorrhagic shock due to fracture injury combined should be weighed against the pros and cons. Third, treatment of fracture-induced redness, swelling, heat and pain can occur after fracture with exudative inflammatory reactions. The clinical symptoms of local redness, swelling, heat and pain are formed, and steroidal and non-steroidal anti-inflammatory drugs have certain efficacy on these symptoms, and the side effects of steroidal drugs have been described before; while the mechanism of action of non-steroidal anti-inflammatory drugs is to inhibit the synthesis of prostaglandins (pg) and weaken the sensitizing effect of pg on inflammatory mediators such as bradykinin. The inflammatory response in the early stage of fracture healing is closely related to pg, which can cause a series of inflammatory responses such as vasodilation of the fracture end, and NSAIDs inhibit pg synthesis to produce therapeutic effects while also inhibiting the vasodilating effect of pg under inflammatory conditions, which makes local blood flow blocked and tissue hypoxia and ischemia, and has adverse effects on early fracture healing. For the redness, swelling, heat and pain in the early stage of fracture, traditional Chinese medicine (such as Panax ginseng, safflower, frankincense, myrrh, etc.) and its preparations can improve these clinical symptoms well, and can improve and promote local blood flow, which is conducive to the early healing and repair of fracture. IV. Prevention and control of deep vein embolism due to venous thrombosis There is a possibility of forming venous thrombosis after fracture. The dislodgement of the embolus with blood circulation can easily cause deep vein embolism or pulmonary embolism and endanger the life of the patient. Anticoagulants can prevent and control thrombosis, but anticoagulants have a certain effect on fracture healing. 1, anticoagulants reduce the fibrin clot at the fracture end and decrease the local calcium concentration. The structure of heparin polysaccharide is similar to that of chondroitin sulfate, and the two form a competitive mechanism, thus reducing the concentration of mucopolysaccharide in the fracture and affecting bone healing. 2. Long-term application of anticoagulants can also form osteoporosis and spontaneous fracture, which can delay bone healing or cause non-healing of fracture. V. Treatment of fracture caused by tumor bone tumor or fracture patients with other parts of the tumor, the use of antineoplastic drugs for chemotherapy is inevitable. The mechanism of action of antineoplastic drugs is to inhibit or kill the growing tumor cells, and because of their poor selectivity, both the growing tumor cells and the normal actively dividing cells will be inhibited or killed by antineoplastic drugs, and the fracture healing cells are also inevitably subject to this fate. In addition, one of the toxic side effects of antineoplastic drugs is bone marrow suppression, which is also extremely unfavorable to fracture healing. In the treatment of pre, intermediate and post fracture complications, it is necessary to weigh the pros and cons and choose the drugs carefully, so as to avoid the waste of drug resources caused by drug errors and to promote the early recovery of fracture patients.