The diseases that cause anal leukoplakia are more common with vitiligo and perianal sclerosing moss, which can be diagnosed by doctor’s examination, related examination and laboratory tests as well as skin histopathological biopsy, and treated for the cause.1. Vitiligo: white spots on the skin, normal or whitened hair within the white spots, with or without skin itching, can appear in any part of the skin and mucous membranes. This disease is more difficult to treat, should be treated early and actively, using a combination of therapeutic treatment, the course of treatment for at least 3 months. Optional treatment methods are: photochemotherapy, glucocorticoids, topical immunosuppressants, etc.; 2. Perianal sclerosing moss: a chronic inflammatory skin mucosal disease. It is common that the mucous membrane of vulva and perianal skin becomes white and thin, and the lesions appear as porcelain white or ivory white papules and plaques. The current treatment of sclerosing moss is mainly symptomatic, but early diagnosis is more important than treatment. Patients are advised to avoid all irritating and fragrant daily products such as soaps. Topical treatment with drugs such as glucocorticoids and calcium-regulated phosphatase inhibitors can be applied topically. Severe cases can be treated with intra-dermal glucocorticoid injections, oral medications such as cyclosporine, and phototherapy as prescribed by the doctor.