1, skin mucosal disease General rheumatism patients will have this obvious symptom, we must be clear that this is a rheumatic disease patients often have a serious disease, not only will deepen the disease, and is the main reason why rheumatism is difficult to treat. Systemic lupus erythematosus, dermatomyositis/polymyositis, leukodystrophy, lipofuscinosis, dry syndrome may have rash, photosensitivity, oral ulcers, vulvar ulcers, eye symptoms, reticular cyanosis, skin ulcers, etc. Qu Xintao, Department of Orthopedics, General Hospital of Jinan Military Region 2, pain During an attack, rheumatism patients will experience significant pain in the joints, internal organs and nervous system. Pain is the main manifestation of rheumatic attacks, and the range of pain is very wide. Pain in rheumatic diseases is most common in joints and their accessory structures, however, pain in limbs and trunk positions can also be seen in visceral and neurological lesions. Joint pain, neck and shoulder pain, low back pain, and heel pain are often the main clinical manifestations of rheumatism, sometimes accompanied by swelling of the joints. What tests are needed for the diagnosis of rheumatism: 1. Blood picture: there is orthocytic orthochromic anemia lymphocytosis and thrombocytosis as a manifestation of the active phase accelerated sedimentation eosinophilia is a symbol of rheumatoid arthritis with severe systemic complications. Hyperviscosity syndrome: rheumatoid factor IgM and IgG complexes can form sticky aggregates causing hyperviscosity syndrome. 3. Rheumatoid factor: lymphocytes and plasma cells in the synovial membrane of patients with rheumatoid arthritis can produce large amounts of rheumatoid factors with IgMIgG and IgA rheumatoid factors. 4. X-ray examination: joint X-ray film can see the joint surface blurred with erosive damage in the early stage of the disease near the joint osteoporosis soft tissue swelling bone erosion phenomenon in the late stage of joint cartilage necrosis can make the joint space narrowing and fibrosis. Analysis of specific rheumatic fever examination items: a. The common clinical examination items of rheumatic fever are blood routine, which may include mild anemia, moderate increase in total white blood cell count and left shift of nucleus. Blood sedimentation increases during the active period, but in heart failure, liver congestion prevents the production of fibrinogen, and blood sedimentation may not increase. In the treatment period with salicylic acid and adrenal corticosteroid, the increase of sedimentation may not be obvious. Streptococcal antibody measurement is the main test item of rheumatic fever. Special protein measurement V. Serum protein measurement The electrophoretic analysis of serum protein during the active period shows a decrease in albumin and an increase in α2 globulin and γ globulin. Immunoglobulins At the beginning of the disease, IgG, IgM and IgA are increased, but in the recovery period, they drop to normal.