The pain on both sides of the wound on the 5th day of lumbar spondylolisthesis surgery may be caused by the incomplete recovery of the local surgical wound. If patients with lumbar spondylolisthesis choose open surgery for treatment, due to large surgical trauma, soft tissue damage, the 5th day after surgery, the surgical wound is still in a state of incomplete healing, is the postoperative tissues are not fully repaired, so there is a pain is a normal reaction to the postoperative period. If lumbar spondylolisthesis patients choose minimally invasive surgery, relatively small soft tissue damage, the wound twice pain, may be due to wound infection preferential, should be observed whether accompanied by repeated wound oozing, non-healing and so on. When the pain on both sides of the wound occurs on the fifth day after the lumbar spine slippage surgery, after excluding the infection, you can take non-steroidal anti-inflammatory drugs under the guidance of the doctor, and take more bed rest, as well as pay attention to the wound cleanliness to avoid infection.