This syndrome is a disease of abnormal skin pigmentation. 1.Skin damage (1) Skin damage manifestation: most of the skin damage of this disease sign is present at birth, and the latest occurrence is at 3 months after birth. Inflammatory stage can occur in the fetal period, and there can be no progress after birth. The first erythema and papules, followed by herpes or blisters, the size of green beans to fava beans, the contents of clear, tense walls of the blisters, stripes or stripes densely arranged, rather than according to the dermatoglyphic pattern or ganglionic distribution. Herpes and blisters last for months and recur. Prevalent in the trunk side, around the breast and limbs and other parts of the herpes, herpes is not broken or broken some oozing, herpes self-absorption or the formation of hard nodules, and then left pigmented spots. Wart-like damage can appear on the back of the hands and feet, especially fingers and toes, and wart-like damage can also leave pigmented spots. Hyperpigmentation can be the only abnormality, or it can be the first manifestation or inflammatory damage, wart-like changes and then appear. The morphology of pigmented spots is peculiar and varied, mostly in the form of irregular splashes, swirls or maps. Its color is gray-blue, dark gray-blue, yellow-brown or black-brown, and the pigmentation is increasing before the age of 2 years, and then gradually becomes lighter with age until it disappears. The pigmentation changes can last for many years and even disappear until the age of 20 to 30. (2) Staging: The skin damage of this disease can be clinically divided into 3 stages, about 1/3 of the cases have a typical development process, most of the cases have an irregular order of the 3 stages, which is easy to become overlapped, and a few cases only have pigmented patches without the changes of the Ⅰ and Ⅱ stages. Stage I: erythema, papule, blister formation or herpes stage, often starting at birth, or within 2 weeks after birth, rarely occurring after 1 year of age. Stage II: Verrucous or mossy rash formation, beginning 2 to 6 weeks after birth. Stage III: hyperpigmentation stage, starting from the 12th to 26th week. About 1/3 of the cases have ocular abnormalities, such as congenital cataract, optic nerve atrophy, optic disk inflammation, retinal hemorrhage, hyperpigmentation, nystagmus, blue sclera and strabismus. About half of the cases may have different degrees of neurological abnormalities, including mental retardation, spastic paralysis and epilepsy. 4. Other manifestations Delayed tooth eruption, embolism, abnormal crown formation of blocked and permanent teeth, thinning hair, scarred alopecia on the top of the head, thin and soft nails with longitudinal and transverse stripes, and so on. In addition, high palatal arches, cleft palate and cleft lip, crural cleft, dwarfism, microcephaly, etc. are rare.