Purpura is not the name of a disease, but a symptom of many diseases, bleeding point in the range of 2-3mm is called purpura, greater than 0.5cm, is called petechiae, according to different etiology and clinical manifestations are divided into many different types of purpura. Purpura is the most common clinical manifestation of hemorrhagic disease, its clinical manifestation is bleeding point, purpura and petechiae, generally not higher than the skin surface, only in allergic purpura can be slightly elevated, the beginning is purple-red, pressure does not fade, later gradually lighten, to about two weeks yellow and fade. The actual purpura is usually a very good way to get the most out of the purpura. The rash is mainly on the lower extremities, especially on the extensor side of both calves. The rash is issued in batches, each batch of about 2 to 3 weeks to subside, due to repeated attacks, the duration of the disease can reach several months to years. This type of general no general discomfort, serious condition has fever, headache and other symptoms. 2, arthritic purpura: when the disease starts, there are fever, sore throat, weakness, nausea and vomiting and other prodromal symptoms, then the skin appears purple glance, wind mass, red spots, even water sores, blood scars, necrosis or ulcers. The skin lesions can occur near the joints, and joint pain is the main feature of this type. The joints that are easily affected include the knee, elbow, ankle and wrist joints. This type can heal itself in a few months to two or three years, but it is easy to recur. 3, gastrointestinal purpura: this type is mostly seen in children and the elderly, because in addition to skin damage such as purple epidemic, there are abdominal pain symptoms, so called gastrointestinal purpura, manifested as the umbilicus or lower abdomen hidden pain or colic, accompanied by loss of appetite, nausea and vomiting, constipation diarrhea and blood in the stool and other symptoms, individual can be accompanied by intestinal overlap, intestinal perforation or even death. 4, renal purpura: children with allergic purpura often accompanied by kidney damage, known as renal purpura, often with hematuria, proteinuria, tubular urine, serious cases can occur renal failure, anuria, swelling, hypertension and other symptoms. If you suffer from this type of allergic purple glance, you should go to the hospital in time to avoid serious consequences. Adults with this type of purple glance have a poor prognosis. 5, mixed type of allergic purpura: is combined with the above two kinds of symptoms for the mixed type of allergic purpura. If you can get rid of the causative factors in time after the onset of the disease and treat the symptoms, it is easier to cure. The general treatment measures are oral vitamin C, calcium (calcium gluconate) and rutin to reduce vascular permeability. Corticosteroids are more effective in treating allergic purpura, especially in reducing arthralgia and gastrointestinal symptoms, but they cannot prevent the appearance of new bruises and prevent kidney damage. The treatment of purpura 1, supportive treatment When the patient has obvious anemia or with heart and lung disease, can be transfused red blood cells. RA and RA-S often cause increased iron load due to repeated blood transfusion. In case of bleeding and infection, platelets can be transfused and antibiotics can be applied. Prophylactic transfusion of granulocytes and platelets has no clear efficacy in patients with MDS. 2.Vitamin therapy Some RA-S are effective for vitamin B6 therapy, 200~500mg/d IV, which can increase reticulocytes and decrease transfusion. 3.Adrenocorticotropic hormone About 10-15% of MDS patients, after applying adrenocorticotropic hormone treatment, the peripheral blood cell count increased significantly, but the side effects brought by corticotropic hormone treatment such as easy infection and increased blood sugar should not be ignored. Some cells in the malignant clone of MDS patients still retain differentiation potential, and some drugs can induce differentiation of tumor cells. Currently, 1,25 dihydroxyvitamin D3, 2μg/d orally for at least 12 weeks, is commonly used. Or vitamin D 3.3 to 600,000 units intramuscularly once daily for 8 to 28 weeks. The blood picture improved in some patients during the administration of the drug. This class of drugs can cause life-threatening severe hypercalcemia, so blood calcium changes should be closely monitored. 13-cis retinoic acid has an induction of differentiation in in vitro culture, but the clinical application is not ideal, domestic mostly use all-trans retinoic acid 20mg three times daily orally. 5.Androgens Ethinyl testosterone (danazol) is currently the most commonly used male hormone, 600~800mg/d for 2~4 months, but there is no exact efficacy. Some reports suggest that male hormones have the potential to accelerate the transformation to acute leukemia. 6. Combination chemotherapy In most cases of MDS, conventional anti-leukemia treatment is not beneficial. mDS has low tolerance to chemotherapy, poor therapeutic efficacy, and even if remission is obtained, the remission period is short. If the patient is younger than 50 years old and in good clinical status for RAEB-T, conventional chemotherapy may be used as appropriate. 7. Bone marrow transplantation When the patient is younger than 50 years old and is in RAEB or RAEB-T, there is an HLA-identical donor and medical conditions allow, allogeneic bone marrow transplantation can be considered.