Patient Question: 4 years after breast-conserving surgery, early pregnancy with low estradiol Happy weekend, Dr. Cheng! I’m sorry to disturb you during your break, I was going to see you in the near future, but I learned that you are closed. First of all, I would like to thank you very, very, very much for the four years of careful treatment, because of your escort, I have a healthy me today, I can feel the feeling of being a mother, I really thank you! Last week when I found out I was pregnant, I immediately went to the obstetrics specialist at the city maternity hospital, and because of low progesterone, I started to rest and take progesterone supplements from the 20th. I was prescribed Estradiol Valerate (6mg per day for two weeks). Here is my diagnosis in 2010: grade III invasive ductal carcinoma, no cancer at the cut edge, radical mastectomy, no metastasis in the axillary anterior lymph. Immunohistochemical staining results:ER(-),PR(-),cerB-2(-),CK5/6(focal+),E-cadherin(+),Ki-67(80%+),p53(++),Top-2(about 60%+),p63(-),EGFR(+). Help wanted: The obstetrician also knows that I have breast disease and that estrogen is related to the breast, so I was asked to consult you again to see if I can take estradiol, and if so, how long I can take it continuously at most, how much the dosage should not exceed at most, and whether there is a red line in the blood test that cannot be exceeded. Thank you Dr. Cheng, I hope to get your help, thank you again! (I couldn’t reach you by text message this afternoon, so I was in a hurry, so I had to consult you here) Doctor’s reply: First of all, congratulations on having a baby. And your type of breast cancer: triple negative is not hormone related, so theoretically you can try to supplement as needed for obstetric treatment. But the problem is that because of the small number of cases like yours, doctors don’t have more reliable information at this time to guide the use of estrogen and progestin and what blood hormone levels would be both safe for the fetus and low risk to the breast. However, I think one principle is to use as little as you can to stabilize the fetus. But how much to use, I think, needs to be regulated by your obstetrician according to the situation. My opinion is: you can use it, just enough, as little as possible. Patient Response: Dr. Cheng, thank you for your prompt reply! Your explanation is very clear, we are much more relieved now, thank you very much! I will download the blue whale doctor software as soon as possible, keep in touch with you, and then go to the clinic to look for you when you return to Beijing. I saw your guest program on Tianjin TV some time ago, very kind! You have a busy schedule, please pay more attention to rest!