What are the early manifestations of SLE? SLE is a systemic disease with lesions in the skin, muscles, bones, heart, lungs, liver, spleen, kidneys, eyes, nose, ears, teeth, and hair. For example: fever, fatigue, loss of appetite, general malaise, joint pain, muscle pain, weight loss, hair loss, facial erythema, red rash on fingertips, white or purple hands and feet when exposed to cold, recurrent oral ulcers, superficial lymph node enlargement, incessant menstrual bleeding, skin purpura, anemia, decreased white blood cell and platelet counts, headache, hallucinations, hallucinations, malaise, persistent diarrhea, vomiting, jaundice, palpitations, shortness of breath, inability to lie down, chest fluid. inability to lie down, presence of pleural fluid, pericardial effusion, etc.