Trigeminal neuralgia is a common painful disorder of the face, and its etiology is not clearly understood. Although the cause of TN is complex, the most commonly accepted theory is that of vascular compression, and clinical results confirm that 80%-90% of trigeminal neuralgia is caused by this theory, and the successful use of vascular decompression also confirms the correctness of this theory. There are many treatment methods for trigeminal neuralgia, and the first choice is pharmacological treatment, including systemic and local medication. The systemic medication of choice for compressive TN is the antiepileptic drug carbamazepine, which is effective in controlling pain in most patients alone, and only a small number of patients need to add or change medication. However, carbamazepine needs to be taken for a long time, with recurrent symptoms after discontinuation, and has significant side effects, and may also interact with other drugs. Oxcarbazepine, a derivative of carbamazepine, has the same therapeutic effect but is well tolerated, does not cause hepatotoxicity, and is used in patients who are intolerant to carbamazepine. In addition, gabapentin, a newer antiepileptic drug, is also effective in controlling trigeminal neuralgia. The initial effect of drug treatment is obvious, but it is difficult to cure trigeminal neuralgia, and it requires long-term medication with large side effects. When drug treatment is ineffective or patients have difficulty tolerating its side effects, minimally invasive treatment or surgical treatment is required. Surgical treatment mainly includes microvascular decompression and balloon compression. 1, microvascular decompression (MVD) is the treatment of TN from the etiological point of view, which pushes the responsible vessels away from the trigeminal nerve root by using isolated materials to release the compression on the nerve root and maintain the nerve integrity, in line with the requirements of functional neurosurgery. It has the highest long-term cure rate and low recurrence rate. However, MVD still has certain surgical risks and some related complications may occur after surgery, such as cranial nerve function impact, cerebrospinal fluid leakage, meningitis, hematoma, etc., or even death due to improper intraoperative rock vein handling, and vascular pressure is not the exact cause of trigeminal neuralgia, so further discussion is needed on when to take this procedure and its impact on prognosis. 2. Balloon compression is a new means of treating TN in recent years, which is to achieve pain relief by mechanically compressing the trigeminal ganglion with a balloon. This procedure has a low probability of corneal injury and is suitable for patients of advanced age or with severe systemic diseases that cannot tolerate larger procedures (including trigeminal nerve branch 1 pain). Clinical studies have reported that balloon compression is preferred for drug-resistant TN patients with multiple sclerosis, which is safe and reliable, has few complications, is highly reproducible, and is easily accepted by patients, but may cause masticatory disorders in patients and has a short clinical application time, so its near and long-term efficiency and complications need further study. 3.Stereotactic radiation therapy is to use γ- knife or radio-wave knife to irradiate a specific area, and the surrounding tissues are rarely injured, which is in line with the modern concept of minimally invasive surgery, avoiding the numbness of the eyes or keratitis caused by percutaneous surgery, so it can be used to treat patients with the first branch of trigeminal nerve pain. γ- knife treatment has the main disadvantage of delayed pain control, and the recurrence rate is high, often occurring facial Numbness, hypesthesia, trigeminal nerve dyskinesia, and even nerve atrophy or displacement often occur. 4.Radiofrequency thermocoagulation of percutaneous perforated hemimelia is a minimally invasive technique that is more frequently used at present. It is to selectively destroy the nociceptive fibers at the trigeminal ganglion through temperature-controlled heating and preserve the fibers of touch, thus providing pain relief and preserving the sense of facial touch. It is a truly minimally invasive procedure with no incision, percutaneous puncture, relatively simple operation, CT-guided puncture, intraoperative electrophysiological testing, high safety, accurate control of target nerve branches, and immediate pain relief after treatment. The indications for radiofrequency thermocoagulation treatment are relatively broad, and elderly patients and patients who have failed surgical procedures or gamma knife surgery can also choose this procedure. The key to successful radiofrequency treatment lies in accurate localization. Traditional puncture localization methods mainly include X-ray plain film, intraoperative CT localization, and simple stereotactic instrument, but for patients with foramen ovale variation, the localization is difficult to be precise, which makes puncture difficult and affects the efficacy of surgery. Our department adopts advanced technology and has developed an intraoperative percutaneous puncture navigation system to assist puncture, which greatly shortens the operation time, reduces patient pain, improves the treatment effect and increases the safety of the operation.