In clinical manifestations, hormone-secreting pituitary adenoma, also known as functional pituitary adenoma, has the following clinical manifestations: 1. Pituitary prolactin adenoma manifestations: For female patients appear to have menstrual cessation due to increased prolactin and decreased estrogen, i.e., amenorrhea, lactation in the breast. Infertility, amenorrhea with inability to have children after marriage. If a woman presents with hyperprolactinemia PRL adenoma accounts for 35.7%, and about 1/3 of infertile patients are due to hyperprolactinemia. In men, hypoactive libido, impotence, gynecomastia, overflow of breast, scarcity of beard, genital atrophy, reduced sperm, low vitality, and male infertility may occur.
2. Pituitary growth hormone adenoma manifests as larger and thicker hands and feet, called acromegaly; metabolic changes: mainly manifests diabetes; respiratory changes: sleep apnea syndrome, snoring, airway narrowing, etc. In cardiovascular changes: left ventricular hypertrophy, heart enlargement, hypertension, etc. In the early stage, there is high energy and inexhaustible neck, and in the late stage, there is low pituitary function performance, such as weakness, no energy, etc., in which the impaired gonadal function is obvious.
3, pituitary gland adrenocorticotropic hormone adenoma performance for women more than men, appear centripetal obesity, polycythemia, full moon face, buffalo back, acne, purple lines, hairy, skin darkening, etc.. There is osteoporosis, often combined with fractures; convulsions caused by low calcium. There is also decreased libido, menstrual disorders, amenorrhea, lactation, infertility, impotence, beard growth and growth of throat knots in women. And there are serious symptoms such as hypokalemia, diabetes, hypertension, and mental disorders.
4. In addition to the above symptoms of high hormone secretion, other symptoms may occur: (1) headache; (2) visual field impairment; (3) other neurological and brain damage, such as hypothalamic dysfunction, but uveitis due to pituitary adenoma is rare; (4) tumor involvement of III ventricle, interventricular foramen, and aqueduct may lead to obstructive hydrocephalus; (5) tumor lateral invasion of cavernous sinus may occur III, IV, V1, VI cranial nerve damage. (5) lateral invasion of the cavernous sinus may lead to III, IV, V1, VI cranial nerve damage and protrusion into the middle cranial fossa may cause temporal lobe epilepsy.