Genital herpes is a sexually transmitted disease caused by infection with HSV-1 and HSV-2 herpes simplex viruses. It is one of the eight major legal STDs, and sexual intercourse and daily contact are the main ways of transmission. Due to the special nature of genital herpes, its treatment cannot be curative, but can only be aimed at relieving symptoms, shortening the course of the disease and preventing recurrence. As it is a herpes simplex virus infection, the main treatment for it is antiviral therapy, which can be taken orally or intravenously with acyclovir, valacyclovir, or famciclovir drugs. In addition, it can also be treated by topical application of interferon ointment, acyclovir ointment, etc. However, avoid using ointments if the patient has erosions or fluid exudation to prevent local infection. If there is significant pain, topical 5% lidocaine hydrochloride ointment or oral painkillers may be used. If the patient is immunocompromised, immune-enhancing therapy can be used, which can inhibit the replication of the virus and reduce the recurrence rate. Patients with genital herpes should pay attention to the prohibition of sexual intercourse during treatment. In addition, patients should take good care of their daily life, live regularly, pay attention to the combination of work and rest, and avoid overexertion.