Although endometrial hyperplastic lesions appear to be a problem of the endometrium, the underlying etiology is actually ovarian dysfunction and endocrine and metabolic disorders of the body. The progestin-based conservative treatment is only for the endometrium, and does not deal with the underlying cause hidden behind the endometrial lesion. Therefore, even if the endometrial lesions are successfully treated, the disease is still prone to recurrence or even progression because the ovarian function is still disturbed and the endocrine and metabolic abnormalities still exist. This explains why many patients develop hyperplastic endometrial lesions soon after treatment, have their endometrium scraped again and again, and even progress to endometrial cancer. Because of this, it is important for patients with endometrial hyperplasia to have successful conservative treatment, but it is even more important to maintain the results and prevent the recurrence of endometrial hyperplasia. Prevention of endometrial hyperplasia: i. Women with fertility requirements: Promoting effective ovulation of the ovaries is the best preventive measure. It is recommended to visit a reproductive endocrinologist for assisted fertility treatment, such as ovulation promotion therapy. These patients are also reminded that due to ovarian ovulatory dysfunction, the chances of natural pregnancy are very low and the vast majority of patients still need assisted reproductive treatment to become pregnant. Second, women without fertility requirements: there are some measures for patients to choose according to their own situation: Periodic oral contraceptives advantages: regular menstrual flow + suppression of ovarian ovulation (contraception + let the ovaries rest), ovaries can re-ovulate after discontinuation of the drug disadvantages: regular use of the drug + may lead to weight gain Note: not applicable to patients with cardiovascular disease, smoking, thrombosis tendency; breast disease patients The IUD should be used with caution or under close supervision; patients with uterine fibroids should be followed up closely; long-term use requires follow-up of liver function Levonorgestrel IUD (Mannorrhea IUD) Advantages: local use, convenient and safe + no menstrual flow or only spot bleeding during placement, especially for patients with dysmenorrhea Disadvantages: more expensive, ring may fall off during use Note: valid for five years, ring may fall off and menstrual dripping Symptoms. Due to the possibility of small amount of absorption into the blood, patients with breast disease should use with caution or use under close supervision for post-progestogenic half-cycle treatment Advantages: regular menstrual flow, perimenopausal women may not have menstrual flow after the use of the drug Disadvantages: regular use of the drug is required + may lead to weight gain Note: patients with breast disease should use with caution or use under close supervision for close follow-up observation Some patients do not want to use any of the above preventive measures because of various comorbidities or other reasons. Some patients are reluctant to use any of the above preventive measures because of various comorbidities or other reasons. In this case, patients are required to closely observe their menstruation. If there is no menstruation beyond the normal menstrual cycle, or if the amount of menstruation is sometimes high and sometimes low, or if the menstrual cycle is sometimes long and sometimes short, it is necessary to go to the hospital promptly. The specific methods of various preventive measures: 1. Periodic oral contraceptives commonly used is Mafulon, in addition to Daying-35, Ursine, etc. can be used. It is recommended to read the instructions carefully before use to clarify whether there are contraindications to the use of the drug. How to use: Start taking the pill from the fifth day of menstruation, once a day, one capsule each time, for 21 days. After discontinuation of the drug, menstruation usually starts in 1-2 weeks, and the next cycle of the drug is started on the fifth day of menstruation. Note that you must take the medication regularly every day, do not miss or stop taking it at will, otherwise it may cause irregular vaginal bleeding. If there is a small amount of vaginal bleeding during the medication period, you can continue to take the medication. If the vaginal bleeding increases like the amount of menstruation, stop the medication or seek medical help. 2.Menstrual ring is forbidden to have intercourse 2-3 days after the menstrual flow. Ultrasound should be done before the IUD is released and consult with the family planning doctor if the IUD is suitable for release. After IUD release, you should follow up regularly according to the doctor’s instruction. 3. Take progesterone 10mg/day for 10 days from the 15th day of menstruation after half cycle of progesterone. After stopping the drug, usually 1-2 weeks after the onset of menstruation, the 15th day of the onset of menstruation and then start the next cycle of drug taking. Note that the medication must be taken regularly every day and must not be missed or stopped at will, otherwise it may cause irregular vaginal bleeding. If there is a small amount of vaginal bleeding during the medication period, you can continue to take the medication. If the vaginal bleeding increases like the amount of menstruation, stop the medication or seek medical help. V. Prevention duration in addition to the Mann Yueh-Le ring can be placed for five years, it is generally recommended that oral contraceptive pills or progestin after half cycle treatment lasts at least 3-6 months. The intermittent pattern of taking three months of pills and three months of rest can also be used. After stopping the prophylaxis, it is necessary to closely observe the follow-up, see “close follow-up”.