Cortisone acetate has a high number of adverse effects and can cause liver impairment, so it should be used with caution in patients with fatty liver. Cortisone acetate is an anti-inflammatory, anti-allergic glucocorticoid drug. It can be used to treat conditions such as hypoadrenocorticism and congenital adrenal hyperplasia due to defects in the enzymes needed to synthesize glucocorticoids, and allergic conjunctivitis. However, it may cause psychiatric symptoms such as excitability and depression; it may also suppress immunity leading to microbial infections such as viruses, bacteria, and fungi; and it may cause side effects such as hypothyroidism, liver function impairment, elevated blood sugar, and peptic ulcers. Therefore, patients with fatty liver should use cortisone acetate with caution, and whether it can be applied needs to be judged according to the severity of their fatty liver and the degree of liver function impairment. Patients with fatty liver must use cortisone acetate under the guidance of a doctor, and self-medication is not recommended.