Proteinuria was first described by Dr. Dekher as early as 1695, but it was not until 232 years later (1927) that the relationship between proteinuria and kidney disease was clarified by Dr. Bright. Later, after numerous clinical and laboratory studies, the importance of proteinuria for the human body was gradually recognized, and it is especially important for kidney disease. Proteinuria is a common clinical manifestation of kidney disease and has always been considered a “consequence” of kidney disease, but in recent years it has become clear that abnormalities in the composition and amount of protein in the urine are not only indicators of pathology, but that proteinuria is also involved as an independent “pathogenic factor” in In addition, proteinuria is also involved in the pathological process of the kidney as an independent “pathogenic factor”, and it is recognized that proteinuria is actually an “endogenous toxin”. Therefore, do not simply think that proteinuria is excreted from the body, but in fact, proteinuria in the body can cause great harm to the body. Proteinuria is not only a large loss of nutritional protein, but also causes damage to the glomerulus, tubules and interstitium, resulting in glomerulosclerosis and tubulointerstitial fibrosis, leading to chronic kidney disease, which can progress to end-stage renal disease (uremia) in severe cases. A large number of scientific studies have confirmed that proteinuria is the “first independent risk factor” for uremia, therefore, the greatest danger of proteinuria is to poison kidney tissue and cause uremia! Therefore, eliminating proteinuria is one of the most important goals of our kidney disease treatment! Of course, the toxicity of proteinuria mainly depends on the amount and duration of the proteinuria, if there is only a transient (temporary) proteinuria, it will not have a big impact on the body.