1. What is percutaneous vertebroplasty (PVP)? Successful vertebral puncture PVP is performed under the precise positioning of X-ray fluoroscopy, a thin puncture needle is passed through the vertebral arch into the diseased vertebral body, and then bone cement is injected, thus strengthening the diseased vertebral body and stabilizing the fracture fragments in the vertebral body, thereby rapidly relieving thoracolumbar back pain and preventing further compression and collapse of the vertebral body. The fractured vertebral body has been reinforced by successful vertebral puncture. 2. Indications for PVP (1) osteoporotic vertebral compression fracture; (2) vertebral metastatic tumor and myeloma; (3) vertebral hemangioma. 3, the application of PVP PVP since the 1990s is widely used in the treatment of vertebral compression fractures and vertebral metastatic cancer caused by osteoporosis. Since 1997, PVP has been recommended in the United States as the treatment of choice for osteoporotic vertebral compression fractures. CUH of Southeast University was the first to perform percutaneous vertebroplasty in China in 2000, and has treated more than 850 cases of osteoporotic vertebral compression fractures, more than 360 cases of vertebral metastatic tumors and 52 cases of vertebral hemangioma until May 2011, with an efficiency of >95% and no serious complications. The main achievements were published in Spine, CVIR, etc., the authoritative journal of spinal surgery and interventional treatment, and won the third prize of Jiangsu Provincial Science and Technology Progress in 2010 and the Chinese Medical Science and Technology Award in 2003, and edited the first domestic monograph on percutaneous vertebroplasty. 11 national courses on percutaneous vertebroplasty have been successfully held in our hospital since 2001, with more than 800 trainees. (1) After the cement is injected into the diseased vertebral body, it takes about 3-4 minutes to completely solidify, and the back pain can be relieved, so the patient can get up and get out of bed independently about 2-4 hours after PVP; (2) Patients with osteoporotic vertebral compression fracture should avoid excessive bending and weight bearing after PVP, but after discharge, the patient should be encouraged to do more outdoor activities and appropriately increase calcium supplementation, take bisphosphonates and apply calcitonin and other anti osteoporosis treatment to slow down the process of osteoporosis. Once severe pain in the thoracolumbar back recurs and cannot be relieved by bed rest for 3~5 days, patients should be highly alert to new fractures in other vertebrae, and magnetic resonance imaging (MRI) examination is preferred; (3) Patients with metastatic vertebral cancer should undergo anti-tumor treatment such as chemotherapy or local radiotherapy despite obvious relief of pain after PVP, and spinal MRI should be reviewed regularly for timely detection of new vertebral metastases.