Cholinergic urticaria occurs without significant correlation with liver lesions and is usually triggered by factors that cause the release of acetylcholine, such as exercise and stress.
Cholinergic urticaria is a specific type of urticaria in which factors such as exercise, mental stress, hot baths, and eating warmer foods can lead to an increase in skin temperature, which stimulates cholinergic nerve impulses in the parasympathetic nervous system, resulting in the release of acetylcholine. The body may be hypersensitive to acetylcholine or lack the enzyme that hydrolyzes acetylcholine, leading to the rash.
There is no evidence to suggest that the development of cholinergic urticaria is associated with liver lesions, and the condition usually subsides some time after onset and does not usually affect the life span of the organism.