Professor Liu Jiaxiang of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, is the director of Shanghai Clinical Medical Center of TCM Oncology, the supervisor of the third, fourth and fifth batches of academic experience inheritance work of national old Chinese medicine experts, and a famous Chinese medicine doctor in Shanghai. He was the first to put forward the idea of “helping the righteous” as the main treatment for malignant tumors, and after more than 50 years of systematic research, he has formed his academic thought of “helping the righteous to cure cancer”. Here, I record a typical case to show his treatment idea. Case Liu, female, 68 years old, was first diagnosed on October 28, 2013. The patient came to the clinic with “recurrent low back pain for more than 3 years, with progressive aggravation for 6 months”. The patient had low back pain without any cause 3 years ago, which was a generalized skeletal pain affecting daily activities and relieved after rest, and was not treated systematically. On June 24, 2013, he went to a central hospital in Shanghai because his low back pain was significantly worse than before, and he went to a lumbar spine MRI scan: L3 vertebral body and accessory bone destruction, compression changes with spinal stenosis, and multiple small nodular abnormal signal shadows in S1, L4, L2, L1 and L5 right transverse processes, which were likely to be caused by metastatic malignant tumor. PET/CT examination in a tertiary hospital in Shanghai in September 2013: multiple bone metastases throughout the body; metastases are likely, and pathological fracture of L3 with spinal canal invasion. Diagnosis: lumbosacral distension and pain, numbness and pain in both legs, pain in the sacrococcygeal region after sitting for a long time, nagging, restful sleep, irregular stools, 2~3 times/day, thin pulse, thin white fur, light texture, tooth marks. Western medicine proposed diagnosis: multiple myeloma? Further clarification of modern medical diagnosis is recommended. TCM diagnosis: bone paralysis (deficiency of both spleen and kidney, cold and dampness blocking the ligaments). Treatment is to benefit Qi and strengthen the spleen, tonify the kidneys and bones, warm the menstruation and relieve pain. We use Douwuxiaosheng Tang and Liuwei Dihuang Tang with Sijunzi Tang as an addition and subtraction. Radix Astragali 30g, Atractylodes Macrocephala 9g, Poria 15g, Radix Rehmanniae 12g, Radix Rehmanniae 12g, Cornu Cervi Pantotrichum 9g, Dampi 6g, Radix Angelicae Sinensis 9g, Radix Paeoniae Alba 12g, Radix Dulcis 9g, Radix Santosiphon 15g, Radix Bonesetter 30g, Radix Chuanjian 12g, Herba Epimedium 15g, Radix Achyranthes Bidentatae 15g, Radix Dilong 30g, Radix Ziziphi 15g, Radix Glycyrrhiza Uralensis 6g, Radix Staphyliniae 30g, Radix Bupleurum Sibiricum 30g, Radix Baiying 15g. Take 1 dose daily with water decoction. Follow-up on January 8, 2014: The patient was diagnosed with multiple myeloma (IgG, κ type, stage IIIA) by bone marrow aspiration biopsy and immunoelectrophoresis at a tertiary general hospital in Shanghai on November 12, 2013 in compliance with medical advice. The patient insisted on taking the above for more than 1 month, and on November 26, 2013, a review was conducted to suggest that: blood β2 microglobulin decreased from 5783ng/mL on November 12, 2013 to 1590ng /ml, serum decreased from IgG:2480mg/dl to 2200mg/dl, light chain κ decreased from 24g/L to less than 0.19g/L,light chain λ decreased from 0.48g /L to less than 0.05g/L, and the indicators decreased significantly. He successfully completed two cycles of VAD regimen (Adriamycin+VDS+DX) chemotherapy on November 27, 2013 and January 4, 2014, respectively. The pulse evidence at the follow-up examination: low back pain, poor appetite, difficulty sleeping, stomach discomfort, weakness, thin coating and red texture, thin pulse. Western medicine diagnosis: myeloma (IgG, κ type, stage IIIA). Traditional Chinese medicine diagnosis: bone paralysis (spleen and kidney deficiency, cold and dampness blocking the ligaments). After taking the medicine, the patient’s back pain was significantly reduced and the pain in the lower limbs had disappeared, suggesting that the medicine hit the disease mechanism and achieved obvious results. This time, the new appearance of gastric discomfort, weakness and poor sleep is related to chemotherapy and hormone use, so we can consider adding products to awaken the spleen and calm the mind. The original formula was supplemented with 6 grams of sand, 24 grams of sour date palm, 15 grams of helianthus bark, and 15 grams of chicken naijin. Continue to follow up for long-term treatment. The disease is characterized by kidney deficiency and blood stasis throughout the disease. Liu Jiaxiang pointed out that the occurrence of this disease is closely related to the “deficiency of positive energy” in the body. The high incidence of the disease is around 50-60 years old, which is considered by Chinese medicine to be the stage of depletion of kidney energy in women and men, and the kidney essence is closely related to the body’s birth, growth, strength, aging and already. If the kidney essence is depleted, the “deficiency of vital energy” is self-evident. Therefore, the pathogenesis of this disease is mainly based on kidney deficiency, deficiency of kidney qi, external infection of evil toxins, internal and external combination of evil, fighting in the bone marrow. Kidney deficiency and poisonous blood stasis are the basic pathological mechanism of the disease throughout. Treatment should be based on tonifying the kidney and strengthening the bones, strengthening the spleen and warming the kidneys, detoxifying and dispersing the toxins and relieving pain. Clear analysis of the pathogenesis and treatment of the disease showed miraculous results. At the time of the first consultation, the patient had obvious back pain, lumbosacral swelling and pain, numbness and pain in both legs, and pain in the sacrococcygeal region after sitting for a long time. Liu Jiaxiang believes that the patient is nearing his seventies, the accumulation of losses is declining, the kidney essence is gradually losing, unable to nourish the bone marrow as the root of the disease, at the same time, the kidney yang cannot warm the spleen yang, then the spleen does not have healthy movement, and the spleen and kidney are deficient, the evidence of internal stagnation of water and drink; the deficiency of kidney yang, the loss of warmth in the external office, the dampness blocking the meridians, the meridians are closed and obstructed, the flow of Qi and blood is not smooth, then the symptoms of the disease. Therefore, the prescription combines the use of Si Jun Zi Tang, Liu Wei Wan and Dou Wu Zai Sheng Tang to achieve the effect of warming the spleen and kidneys, tonifying both qi and blood, resolving dampness, clearing the channels and relieving pain. After 1 month of administration, the patient’s back pain was significantly relieved and the patient’s quality of survival improved significantly. Particularly important was that tests performed before the first chemotherapy had already revealed that blood β-microglobulin decreased from 5783ng/ml to 1590ng/ml, IgG decreased from 2480mg/dl to 2200mg /dl, light chain κ decreased from 24g/L to less than 0.19g/L, light chain λ decreased from 0.48g/L to less than 0.05g/L, KAP/LAM decreased from This suggests that the clinical symptoms and biochemical and immunological tests of the patients indicate significant improvement. A clear diagnosis of the disease can improve the efficacy of the treatment. Liu Jiaxiang believes that Chinese medicine and modern medicine have different methods of understanding disease, but the object of understanding is the diseased organism, and understanding disease from both macroscopic and microscopic perspectives can help to grasp the disease as a whole. Therefore, when he encounters tumor patients whose diagnosis is not clear in modern medicine, he tries to clarify the diagnosis as much as possible from different levels such as imaging, pathology and molecular pathology, so as to make up for the deficiency of microscopic diagnosis in Chinese medicine and improve the efficacy of evidence-based treatment. For example, in this case, the patient came to the clinic with lumbar pain as the main symptom, lacking a clear modern medical diagnosis. Based on his clinical experience, Liu Jiaxiang recognized that the patient might be suffering from multiple myeloma, and thus promptly suggested the patient to undergo pathological examination to clarify the diagnosis, and then completed two chemotherapy treatments to obtain timely diagnosis and treatment. At the same time, the drugs used in this case were Shi Mian Pang, Bai Hua Shi Tong Cao, and Bai Ying, which he had already considered that the patient might have multiple myeloma, and then prescribed the drugs in consideration of the presence of internal accumulation of dampness and toxicity. This case also reminds future students that as a TCM specialist, they should also have a broad knowledge of modern medicine, so as to achieve the basic requirement of seeing the smallest details, detecting problems in time and not misdiagnosing them as much as possible.