Epilepsy is a more common disease, and some of them are not cured for a long time, and repeated treatment becomes intractable epilepsy, chronic epilepsy, which is difficult to cure with various drugs and extremely difficult, often bringing great distress and anxiety to patients and families. Specifically, intractable epilepsy is defined as a condition that does not remit after 2 to 3 years of long-term high-dose multiple antiepileptic drugs (AEPS) and the convulsions remain. Some physicians further define intractable epilepsy as those who have used adequate doses of first-line AEPS monotherapy or multi-drug combinations after the diagnosis of epilepsy, and whose blood levels have reached therapeutic levels, but still have difficulty in achieving complete control for a long enough period of time (2 to 3 years). Why does it become intractable? The etiology is quite complex. It is generally believed that the following conditions are involved: (1) delayed initial treatment (2) frequent seizures or a tendency to persist in each episode (3) a tendency to develop intractable epilepsy if the epilepsy is grand mal or atonic epilepsy, or if there is cerebral tuberous sclerosis or diffuse neuroma. In fact, any type of epilepsy can evolve into intractable epilepsy, but the proportion varies. The first step is to find out the true cause of epilepsy, and there is no unified treatment model, so the first step in treatment is to build confidence and patience, and to stop being discouraged. The first step is to carefully identify the real cause of the disease. In the specific measures can be taken according to different causes, medication, surgery, psychological behavior therapy, vagus nerve electrical stimulation therapy and sports, diet and other comprehensive treatment. Of course, the first choice among the above methods is still mainly drug therapy. As for the high dose of monotherapy or combination of drugs, it depends on the specific patient. One key, one lock, don’t force it. It is important to note that the side effects of medications and the patient’s ability to tolerate them should not be ignored in order to control epilepsy. The dose should be increased, otherwise the benefits are not worth the losses, and there are many disadvantages. Adjuvant drugs (e.g., nimodipine, flunarizine, etc.) can also be applied to enhance the effect of AEPS. As for the indications for surgical procedures, temporal lobe epilepsy is currently the most popular choice. As for the other methods mentioned above, they can be applied as appropriate, in order to consolidate and expand the efficacy of AEPS and to support the root cause. In conclusion, as long as the cause is recognized, the treatment is appropriate, and the doctor and patient cooperate, intractable epilepsy can be transformed into intractable but not stubborn, and then cured.