As a necessary medication, for most menstruating women, spironolactone tablets can usually be taken under the guidance of a doctor, provided that their periods are normal and they are menstruating. However, long-term consumption of spironolactone tablets may cause women to experience adverse reactions such as breast pain, irregular menstruation, and decreased sexual function. Spironolactone tablets are a diuretic drug mainly used to treat edematous diseases such as congestive edema, nephrogenic edema and cirrhotic ascites, and also as an adjunctive treatment for hypertension, as well as to prevent the occurrence of hypokalemia. However, long-term consumption of spironolactone tablets may lead to adverse reactions such as hyperkalemia, nausea, vomiting, stomach cramps, hyponatremia, hypogonadism and menstrual irregularities. In general, women with normal periods who take spironolactone tablets briefly during their menstrual period usually do not have a major impact on their body or menstruation. However, patients who already have irregular periods and enlarged breasts should use spironolactone tablets with caution to avoid aggravating menstrual disorders. Women should also pay attention to perineal hygiene during menstruation, keep warm, change underwear and sanitary napkins regularly, and avoid catching cold and eating cold food to prevent menstrual cramps.