According to this time period, it is recommended that drugs such as Nifta should be taken orally twice a day, before these two times. After the two peaks, the trough of blood pressure occurs, and this trough of blood pressure is at 2-3 am at night. So for people with hypertension, if monitoring blood pressure it is generally recommended to measure blood pressure in the morning and at night before sleep to see the state of blood pressure fluctuations within 1 day, if the range of blood pressure fluctuations is too large, it is necessary to adjust the drugs according to the situation, such as the application of long-acting preparations, like Bexinom, Irbesartan, etc. This drug will calm down the blood pressure within 24 hours, which will help the patient’s blood pressure control without excessive fluctuations.