Patients with epilepsy who have an indication for infection can use azithromycin, which will not aggravate the patient’s epileptic phenotype. Azithromycin is a macrolide antibiotic that is more commonly used clinically for lower respiratory infections such as bronchitis and pneumonia, and for upper respiratory infections such as sinusitis, pharyngitis, and tonsillitis. There is also azithromycin that can be used when skin and soft tissue infections occur. The first aspect is that the medication must be taken under the guidance of a professional physician for reasonable use; the second aspect is that the medication should be used in small doses and as a single drug as possible. If the effect is not good, you should combine the drugs under the guidance of the doctor; third, patients can not arbitrarily stop the drugs on their own, if the drug symptoms, you need to gradually reduce the amount under the guidance of the doctor, and during the period of taking anti-epileptic drugs, to regularly review the patient’s liver function, blood sugar, blood routine.