Parkinson’s disease is a common neurological dysfunction disease, the symptoms of which are involuntary tremor of the hands, head or mouth at rest, muscle stiffness, slow movement and postural balance disorders, etc., and in severe cases, the patient cannot take care of himself/herself. Parkinson’s disease drug treatment is now the choice of most people, the use of drugs to control Parkinson’s symptoms, the initial effect is better, but then will produce side effects, but also cause the phenomenon of switch, Parkinson’s disease drug treatment should pay attention to what? And what are the contraindications? 1, three meals less protein food, such as meat and dairy products. Milk can be decomposed in the intestinal tract to produce a large number of amino acids, amino acids can hinder levodopa in the intestinal tract, so that its efficacy is reduced. The best time to take levodopa is 30 minutes before meal, followed by 1 hour before meal or 2 hours after meal. This kind of drug will reduce the absorption rate if it is taken with food. 3, prohibit calcium antagonists, such as nifedipine, a class of antihypertensive drugs between the antagonistic effect of drugs to reduce the efficacy of drugs. 4, prohibit acetylcholine Because Parkinson’s disease is due to hyperfunction of the acetylcholine system resulting in increased muscle tone, decreased movement, muscle tremor, so should pay attention to the intake of acetylcholine drugs. 5, prohibit vitamin B6 6, prohibit gastrointestinal dynamics drugs, such as morpholine Because gastrointestinal dynamics drugs have the effect of blocking dopamine, promote gastric emptying, reduce the absorption rate. 7, glaucoma patients with caution Because dopamine is a drug that can elevate blood pressure, there is a certain effect on intraocular pressure, so you need to pay attention to changes in intraocular pressure during the drug. Medication plays an important role in the pre-treatment of Parkinson’s disease, which can effectively control the development of Parkinson’s disease, but some drugs contain side effects, and prolonged use will have an impact on patients. When the effect of medicine decreases, the effect of medicine fades quickly or adverse reactions occur, receiving brain pacemaker surgical treatment at this time can obtain obvious efficacy. Moreover, if the patient receives a pacemaker at this time, he or she is much more likely to regain the ability to lead a normal life and work after the surgery than a patient with advanced Parkinson’s disease. Deep Brain Stimulation (DBS) is a minimally invasive procedure that causes minimal damage to the human body, improves symptoms in both limbs at the same time, results in rapid recovery, reduces the need for anti-Parkinsonian medication and improves quality of life.