Whether amoxicillin can be used to treat pneumonia depends on the causative agent of the infection and the condition. Amoxicillin is not effective in viral pneumonia because it is a penicillin antibiotic and cannot be used to treat viral pneumonia unless it is combined with a combination of bacterial infections. For pneumonia caused by mycoplasma, chlamydia, and legionella infections, amoxicillin is also ineffective for this causative agent, and patients mostly need to choose anti-inflammatory treatment with fluoroquinolones and macrolides. For mild pneumonia caused by non-drug-resistant bacterial infections, amoxicillin can be used to treat pneumonia, but if it is due to drug-resistant bacteria and severe pneumonia, amoxicillin cannot treat such pneumonia. Patients mostly need to choose sensitive antibiotics and perform strong anti-inflammatory therapy with symptomatic treatment. Therefore, when pneumonia occurs, it is important to select the appropriate anti-infective drugs according to the causative agent of the infection and the condition to improve the cure rate.