Currently, commonly used antihypertensive drugs are divided into five major categories, each with different characteristics. When hypertension is combined with nephropathy, the antihypertensive treatment should choose angiotensin-converting enzyme inhibitors (ACEI), represented by captopril, fosinopril, benazepril, etc., or angiotensin II receptor antagonists (ARB), represented by valsartan, irbesartan, temisartan, etc. ACEI drugs can reduce urinary protein and microalbumin in patients with hypertensive nephropathy. ACEI drugs or ARB drugs can delay the deterioration of renal function in the early and middle stages of hypertensive nephropathy, but in the late stage of the disease, the renal function deteriorates, so the antihypertensive treatment of hypertensive nephropathy should be based on the situation of renal function and selected by the doctor after consultation. Therefore, the antihypertensive treatment for hypertensive nephropathy should be based on the renal function and selected by the doctor after consultation. In general, creatinine over 221umol/L should be used with caution.