Cholestatic cirrhosis is a series of organic damage and liver dysfunction caused by the accumulation of bile in the liver due to various causes of impaired bile production, secretion and excretion. The common causes of cholestasis are genetic, immune, infectious and tumor factors. In terms of treatment, cholestatic cirrhosis cannot be completely cured, and it is very important to treat the primary disease. Cholestasis can cause vitamin absorption disorders, and vitamins should be given for treatment if necessary, and ursodeoxycholic acid and liver-protective drugs should be applied.