Diabetic peripheral neuropathy is one of the three most common complications of diabetes mellitus, and the disease is insidious and can precede the onset of diabetic symptoms. Diabetic peripheral neuropathy is characterized by early involvement of sensory nerves, with painful numbness in the limbs as a prominent feature. The clinical manifestations are mainly peripheral nerve symptoms, bilateral or unilateral, symmetric or asymmetric, but symmetric damage is more common. The lower extremity is heavier than the upper extremity, with abnormal sensation at the extremity, numbness and ankle sensation. The patient’s sensory and motor functions of the extremities are severely affected by pain, numbness, coldness, weakness and muscle atrophy. The patient’s sensory loss or loss of sensation, especially to cold, hot and painful stimuli, can sometimes lead to very dangerous situations. For example, if a foot injury occurs when a patient steps on a foreign object but does not feel pain, he or she will not be aware of it in time, or if he or she is scalded by hot water. In some cases, the pain is so pronounced that the patient often wakes up in pain and has difficulty sleeping, which seriously affects the patient’s quality of life. As patients have difficulty sleeping, lack of sleep affects the quality of life, fatigue, irritability or depression. However, it worsens as the disease progresses. Diabetic peripheral neuropathy can involve the motor nerves and may result in hypotonia, muscle weakness, muscle atrophy and paralysis, hyperactive Achilles tendon and knee tendon reflexes in the early stages, but in the late stages, hypoacusis, perception, temperature and position sensation. Some patients with autonomic neuropathy may experience dizziness, panic, blackness, tinnitus, or even fall or confusion due to the lack of blood supply to the brain, which is due to the lesion of the nerves innervating the heart. When the autonomic neuropathy of the reproductive system is affected, the patient may suffer from dyspareunia, oliguria, incomplete urination, urinary retention, and urinary tract infections, while the neuropathy of the reproductive system may manifest itself as hypoactive libido and impotence in men. The brain nerves may be affected by facial palsy, droopy eyelids, blurred vision, and other symptoms. Patients with these symptoms need to be alerted and can be treated early if subclinical nerve damage is detected by neuromyography to avoid delays. The most important thing in treating diabetic peripheral neuropathy is to control blood sugar, in addition to improve microcirculation, improve the blood supply and oxygen supply to nerve cells, which can promote the repair and regeneration of damaged nerve cells. Use some blood activating and nerve nourishing drugs, such as vitamins and nerve growth factor, to cooperate with the treatment.