The patient, male, 77 years old, was diagnosed with “coronary artery disease, acute myocardial infarction” and underwent coronary intervention with one gyral branch stent 10 years ago due to anterior heart pain with no obvious cause, accompanied by sweating, nausea and vomiting, which persisted without relief. After being discharged from the hospital, he took medication regularly and had no symptoms of chest pain. In the past three months, he had a recurrence of chest tightness after activity, with more and more frequent episodes, and the coronary angiography indicated coronary artery disease with three branches. CT of the aorta revealed severe calcification of the aorta with “tube-like changes”. Due to the patient’s previous history of old myocardial infarction, type II diabetes mellitus, hypertension, and severe stenosis of the internal carotid artery. Since conventional bypass and PCI treatments were not effective, President Wu Qingyu instructed the patient to undergo cardiac hybridization after the inspection. Dr. Zhang Mingkui, the chief physician, performed “end-lateral anastomosis from the left internal mammary artery to the anterior descending branch” under the beating heart to ensure the blood flow of the anterior descending branch and long-term efficacy, and Dr. Miao Lifu, the deputy chief physician, performed PCI (percutaneous coronary intervention) and placed two stents to achieve complete revascularization. Cardiac hybridization is an effective treatment for severe coronary artery lesions, and is suitable for elderly patients with severe coronary artery disease combined with cardiac insufficiency, renal insufficiency, diabetes mellitus, severe carotid artery stenosis, and severe calcification of the ascending aorta. Cardiac hybrid surgery is a new method of treating patients with severe coronary artery disease that requires the cooperation and collaboration of a hybrid surgery treatment team consisting of cardiac surgery, cardiology, radiology imaging, anesthesiology, operating room and catheterization laboratory.