Mastocytosis is associated with endocrine disorders and psychological factors. The decrease of luteinizing hormone secretion and the relative increase of estrogen are the important causes of this disease. The pathological manifestations of mastocytosis are mainly benign hyperplasia of the interstitial mammary glands, which can occur around the ducts and be accompanied by the formation of cysts of various sizes; they can also occur in the ducts and appear as papillary hyperplasia of the epithelium, accompanied by cystic dilatation of the milk ducts. Elevated prolactin is also an important factor in the development of mastocytosis. In addition, some studies have shown that hormone receptors also play an important role in the pathogenesis of mastocytosis. Various factors such as neurological, immune and trace elements can cause imbalance of various endocrine hormones in the body. The external environment, work and living conditions, interpersonal relationships, and neuropsychological factors caused by various stresses can change the internal environment of the human body, thus affecting the function of the endocrine system and causing abnormalities in the secretion of one or more hormones. For example, in a state of chronic stress and anxiety, opioid tension is increased, the neurotransmitter-mediated environment is altered, and estrogen/dopamine disharmony occurs, which leads to increased secretion of PRL, which may cause or aggravate mastocytosis.