There are many reasons for the spots at the corners of the eyes, and the common ones are as follows: Firstly, endocrine disorder, if the patient has endocrine disorder, especially the abnormal hormone secretion level, it will lead to pigmentation. Second, long-term oral intake of certain drugs, such as birth control pills and androgens, will lead to abnormal hormone secretion level, which will lead to long spots at the corners of the eyes. Thirdly, mental stress, life stress or long-term depression and emotional depression will lead to long spots at the corners of the eyes. Fourth, sun exposure, long-term ultraviolet radiation will lead to facial pigmentation, which will cause skin spots at the corners of the eyes. Fifth, congenital diseases, such as nevus of Ota, coffee spots, etc. Sixth, seborrheic keratosis, sun exposure, skin aging, etc. can induce the appearance of seborrheic keratosis, also manifested as long spots on the face.