Women’s eye spots, black corners of the mouth may be caused by seborrheic keratosis with keratitis, chloasma or pigmented dry dermatosis. 1. Seborrheic keratosis: also known as basal cell papilloma, is a common benign proliferative tumor of the epidermis in the elderly, which can occur on the face, with a varying number of light brown flat papules or plaques, slightly above the skin surface. If patients have keratitis or long-term glucocorticoid ointment on the lips at the same time, the symptom of darkness on the corners of the mouth with long spots on the corners of the eyes can appear. 2. Melasma: yellow-brown pigmentation spots on the face, related to pregnancy, endocrine disorders, ultraviolet irradiation, etc. It can be seen as yellow-brown or coffee-colored patches on the cheekbones, perioral area, nose, etc., with deepening of pigmentation after sun exposure. When chloasma area is large, it can lead to the symptoms of darkness at the corners of the eyes and mouth. 3. Pigmented dry dermatosis: freckle-like rash can occur in childhood, appearing on the face, neck and other skin, and when the patient is 3-4 years old, the yellow-brown patches are obvious and gradually increase, resulting in the symptom of darkness at the corners of the eyes and mouth. When women have spots at the corners of their eyes and darkness at the corners of their mouths, it is recommended that they go to regular hospitals in a timely manner to clarify the nature of the spots and the cause of darkness at the corners of their mouths, and follow the doctor’s instructions for treatment.