Scientists believe that fertility is the continuation of the human race, while a family continues its life or passes on the family line through childbirth. No matter which way you look at it, fertility is a natural thing, but it is such a reasonable thing, but sometimes it is so difficult to achieve: some couples have no abnormalities found in premarital maternity examinations, and they do not take any contraceptive measures after marriage, but they never get pregnant, or even if they are lucky enough to get pregnant, they cannot avoid the end of multiple miscarriages. Some families visit famous doctors in order to conceive a baby, all kinds of tests, laboratory tests, even surgery were done, but did not find a reason. After that, they try all kinds of legendary “miraculous” local and ancient remedies, but still nothing happens. The ability to conceive a healthy baby has become an unattainable thing for them. In China, the importance of children to the family can not be overstated, especially for women, it is more important. The constant failure to conceive a baby makes both men and women accumulate great pressure from each other, their parents and society, and children sometimes even become the guarantee of family happiness and harmony. Therefore, in the following, I will briefly explain the general process of pregnancy and some of the causes of infertility, focusing on those “abnormal immune problems” that cause infertility but are often overlooked. We hope that the following explanation will provide some useful information to solve your problem. In order to have a properly developed baby, sperm from the father’s “vibrant” body must travel thousands of miles to the woman’s “vagina, uterus and fallopian tubes” and then successfully “fertilize” the egg that is waiting there “to form a “fertilized egg”. The fertilized egg then returns to the mother’s uterine cavity, and in the process of returning to the uterine cavity, the “fertilized egg” gradually divides and becomes an “embryo” which, upon returning to the uterine cavity, finds a suitable “place “This is called “implantation”. After implantation, the mother provides protection and nutrition for the embryo, and if no accident occurs, the embryo is gradually formed into a fetus under the “nourishment” of the mother, and then grows to full term to give birth to a healthy baby. In summary, we know that pregnancy is a joint venture between a man and a woman, so when infertility occurs we have to look for the cause in both men and women respectively. The majority of causes of infertility are female factors, so after excluding reasons such as the father’s sperm “failure”, we mainly focus on the mother. Common causes of infertility in women include failure to ovulate normally, abnormal secretion of pregnancy-related hormones, congenital or secondary anatomical abnormalities of the reproductive system, abnormal maternal immune function, as well as genetic and psychological factors. If for some reason the maternal immune system produces an excessive immune response to its own tissues, resulting in an overpowering series of immune reactions, the normal physiological functions of the mother will be altered. Maternal immune abnormalities can result in the production of various antibodies, such as anti-sperm antibodies (AS Ab), anti-ovarian antibodies (AO Ab), anti-endometrial antibodies (EM Ab), anti-chorionic gonadotropin antibodies (hCG Ab), anti-cardiolipin antibodies (AC Ab), or the maternal production of protective “closed antibody (APLA) ” is insufficient. It has been shown that autoimmune antibodies are strongly associated with the occurrence of unexplained infertility and poor pregnancy outcomes (e.g., embryonic abortion, miscarriage). For the action of these antibodies, for example, anti-sperm antibodies kill sperm from the father directly, causing these sperm to die at the starting line directly after entering the mother’s body, so that subsequent matters such as fertilization do not occur at all and infertility is inevitable. Anti-coagulant antibodies may cause placental circulation disorders by inducing placental thrombosis, resulting in fetal hypoplasia or fetal death due to insufficient blood and oxygen supply to the fetus. Anti-ovarian antibodies and endometrial antibodies can affect pregnancy by affecting the normal physiological functions of the ovaries and uterus. Under normal circumstances, the mother also produces a protective antibody (closed antibody (APLA)) that prevents the embryo from being attacked by the maternal immune system. Insufficient production of immune antibodies can lead to strong rejection of the fetus by the mother, which can lead to recurrent spontaneous abortions in early pregnancy (1-12 weeks) and to hypertensive disorders of pregnancy, fetal failure, and even fetal death in late pregnancy (28 weeks to the end of labor). From the above, we can know that maternal immune abnormalities can have a serious impact on the outcome of pregnancy. When faced with infertility problems, it is important to pay attention to check autoimmunity and detect autoantibodies and other conditions to help clarify the cause of infertility in order to guide further treatment and prepare for pregnancy. And for those who are infertile, when you feel overwhelmed with infertility, ask yourself again if you are aware of immune-related issues?