There is no optimal medication for chronic urticaria, which can be treated by using antihistamines, immunosuppressants, biologics and so on. 1. Antihistamine drugs: the treatment of chronic urticaria is based on antihistamines, which can reduce itching and accelerate the regression of wind masses. Such as cetirizine, diclofenac tadine, etc., lactating women should be used with caution. If an antihistamine fails to control symptoms, it can be replaced with other varieties or increase the dose or more than two kinds of combination drugs, increase the dose. 2. Immunosuppressants: If antihistamines are ineffective, cyclosporine, azathioprine and other immunosuppressants can be used in combination. 3. Biological agents: For refractory urticaria, biological agents such as omalizumab can be considered for treatment. In addition, for patients with urticaria who are ineffective on antihistamines, glucocorticosteroids such as prednisone can be applied under the guidance of a doctor in case of emergency, such as laryngeal edema and respiratory distress. Urticaria patients are advised to go to the hospital in time, follow the doctor’s instructions for standardized treatment, do not self-medication.