Masses left behind by healed tissue after a fracture or by certain diseases such as bone tumors are called skeletal masses. The skeletal system, like other organs, can develop tumors from any tissue component or metastatic lesions from other organs. Tumors that invade the bone can occur in the bone cells, the hematopoietic component of the bone, the cartilage, and the fibrous or synovial component. Other tumors may arise from the muscles and nerves, blood vessels, and fatty tissue of the bone. Bone masses may not be felt at first, but may become swollen and painful when the mass is larger. The affected area is painful, and there are localized lumps and swelling in the joints and limbs. The movement of the affected joints and limbs is limited. Localized bones are often found in the flat bones, especially in the sternum, ribs, skull, clavicle, and mandible, etc. Localized bones are elevated, hard to touch or rubbery and soft to the touch, with elasticity or sound when pressed, and localized pressure pain. Tumor tissue commonly infiltrates nearby soft tissues, and bead-like changes in the sternum, ribs, and jaw joints are seen in half of the patients. Multiple myeloma: Bone masses are mostly found in flat bones, especially in the sternum, ribs, skull, clavicle, and mandible, etc. Local bones are elevated, hard to touch or rubbery and soft, with elasticity or sound when pressed, and local pressure pain. The tumor tissue commonly infiltrates the nearby soft tissues, and bead-like changes in the sternum, ribs and jawbone joints are seen in half of the patients. 2.Guaiac tissue: Clinical manifestation symptoms: swelling, edema, bony shoulder mass, local mass of bone swelling, bone X-ray examination.