(1) Male with pediatric patients, the possibility of cancer is high, about 50% of them are cancerous and should be alerted. (2) Sudden increase in size within a short period of time. (3) Produce symptoms of pressure and invasion: such as difficulty in whistling, hoarseness, difficulty in swallowing, etc. (4) The swelling is hard and solid with uneven surface. (5) The swelling is restricted in movement or fixed and does not move up and down with swallowing. (6) Enlarged lymph nodes in the neck (7) Re-appearance of thyroid swelling or enlarged lymph nodes in the neck after thyroid surgery (7) Ultrasound suggests unclear boundary of the mass, incomplete envelope, internal inhomogeneity of the mass, abundant blood flow, fine gravel calcification, and papillary structures.