There are two main causes of high serum uric acid: increased uric acid production and decreased uric acid excretion, respectively, and sometimes both. Uric acid is the end product of purine metabolism and is mainly produced by the enzymatic breakdown of nucleic acids and other purine compounds from cellular metabolism and purines from food. The saturation and concentration of uric acid in the body is about 420 μmol/L (7 mg/dl) at 37°C. Above this concentration, hyperuricemia is considered. Increased uric acid production: It mainly includes both dietary intake of high purine foods and increased endogenous production of purine metabolism. If you consume too much high purine food in your daily life, and if your colleagues have metabolic problems, you will have increased uric acid. Decreased uric acid excretion: About 2/3 of uric acid is excreted through the kidneys, and if there are problems with the kidneys, the excretion of uric acid can be affected, which is manifested as increased uric acid. Some medications or alcohol consumption can also affect the excretion of uric acid and lead to an increase in uric acid. In general, the increase of serum uric acid is mainly caused by the increase of uric acid production and the decrease of uric acid excretion, but the exact cause and the specific effect of which area is to be determined by the patient’s medical history and related tests.