Chemotherapy is a necessary treatment after liver metastasis of colon cancer. At present, for liver metastasis of colon cancer, radiotherapy, chemotherapy and surgery should be adopted in close cooperation, with the aim of curing liver metastases by surgical resection as much as possible. Because research shows that only after radical surgery to remove liver metastases, long-term survival of colon cancer liver metastases is possible. Therefore, once liver metastasis of colon cancer occurs, it is necessary to cooperate with chemotherapy, targeted therapy, radiofrequency ablation and other therapeutic means to transform unresectable liver metastases into liver metastases that can be removed by the above means and then removed by radical surgery, so chemotherapy is a necessary treatment after liver metastasis of colon cancer.