Persistent status epilepticus is a common medical emergency. If left untreated, patients may suffer from high fever, respiratory and circulatory failure, and electrolyte disturbances leading to permanent brain damage, and should be treated promptly. Treatment of persistent epilepsy aims to maintain stable vital signs and cardiopulmonary support; terminate seizures and reduce seizure damage to neurons in the brain; find and eradicate causes and triggers when possible; and manage complications. Treatment of persistent epilepsy includes general management and drug therapy. General management refers to keeping the airway open, administering oxygen, tracheotomy if necessary, monitoring the patient’s vital signs, establishing intravenous access, and actively preventing cerebral edema and infection. The first-line drugs such as diazepam, clonazepam, phenobarbital and phenytoin sodium are preferred for the pharmacological treatment of patients with persistent epilepsy. Patients with refractory status epilepticus who are not treated with the above drugs and have continuous seizures for more than 1 hour can be treated with isopentobarbital, midazolam, propofol, and lidocaine to rapidly terminate the seizures. After the seizures have stopped, the cause of status epilepticus should be actively sought and treated, and various complications should be treated. If the seizure does not stop on its own for more than 5-10 minutes, the patient should be sent to the hospital for emergency treatment to terminate the seizure in time and reduce the disability rate.