For many years, the saying that “Chinese medicine has few side effects” has made people lack sufficient awareness and attention to the hepatic and renal toxicity of proprietary Chinese medicines, and some children with precocious puberty are forced to take proprietary Chinese medicines for years and months. In recent years, there is an increasing trend of patients with nephritis and acute renal failure caused by indiscriminate use of Chinese herbal medicines. We appeal:It is necessary to raise awareness of herbal medicine nephrotoxicity. In the mid-1990s, Belgian doctors first discovered that a considerable number of “fat girls” and “fat sisters-in-law” suffered from acute kidney failure after taking weight-loss herbs without any taboos. This led to the concept of “Chinese medicine nephropathy”. According to the research report of the Institute of Nephrology of Nanjing Military General Hospital, the “aristolochic acid” contained in the Chinese medicines Moutong, Houpao, Fantao and Hesperidin can lead to renal tubular and interstitial, proximal tubular acidosis and hypotonic urine. These patients initially present with oliguric acute renal failure, which over time turns into chronic tubulointerstitial nephritis. And these patients are extremely difficult to treat, often gradually towards end-stage failure. Experts stressed that many charlatans are currently abusing Chinese herbal medicine to treat various kidney diseases under the banner of “partial prescriptions” and “experimental prescriptions”, which aggravate the condition of patients and even lead to uremia, which must be vigilant. 2, which Chinese medicines are toxic to the kidneys The Chinese Society of Integrative Medicine Nephrology Committee experts found that nearly 50 kinds of Chinese medicines are toxic to the kidneys and can cause acute and chronic kidney function damage and kidney failure. There are three categories of these Chinese medicines that can cause kidney damage. The first category is plant-based Chinese medicine: Lei Gong Vine, Cao Wu, Mu Tong, Jun Zi, Yi Mao Cao, Cang Er Zi, Neem Bark, Smallpox Powder, Petunia, Golden Cherry Root, Euphorbia, Horsetail, Euphorbia, Crocus, Iron Foot Wailing Fairy, Da Feng Zi, Mountain Cichorium, Mandarins Flower, Di Di Di Feng, Pinellia, Da Qing Ye, Ze Xie Di, Fang Shen, Gan Sui, Qian Li Guang, Clove, Ming Vine, Bupleurum, Bupleurum, Dwarf Earth Tea, Bitter Ginseng, Earth Hyssop, etc. The second category is animal herbal medicine: fish gall bladder, seahorse, centipede, snake venom, etc. The third category is mineral herbal medicines: arsenic (arsenic, arsenicum, stannum, red alum), mercury (cinnabar, mercury, light powder), lead (lead pellets) and other minerals (alum), etc. Most Chinese medicines are natural medicines with complex active ingredients such as alkaloids, saponins, tannins, volatile oils, and so on. Since they are medicines, most of them have different degrees of side effects. Generally speaking, the side effects of Chinese medicines are less than those of synthetic western medicines, but some of them are more toxic, such as red arsenic, white arsenic, mercury, spotted cucumber, green maiden worm, red maiden worm, raw garcinia, and so on. The less toxic ones are: white aconite, raw aconite, raw szechuan wu, raw herbaceous wu, raw half asia, strychnine, croton, raw tiannanxing, raw gansui, haunting flower, tianxianzi, toadstool, turtle, luzon fruit, cloud axis seed, maple seed, maple flower, raw sulphur, croton cream, white descending dan, poppy shell, etc. When using these drugs, must be careful, such as maple front flower infusion, orally can treat rheumatoid arthritis, too large a dose, often cause death by poisoning. Therefore, toxic herbs must be taken under the guidance of a physician. 3, how to safely use the Chinese herbal medicines We usually commonly use in the Chinese herbal formulas of half asia, tiannanxing, sophora, Chuanwu, grass wu, etc., why does not occur poisoning? On the one hand, these drugs have been concocted before the pharmaceutical, such as raw half a summer will cause vomiting, lips and tongue numbness, hoarseness and other side effects, and raw half a summer with ginger, alum, salt and other concoction, its toxicity is greatly reduced; on the other hand, but also to master the correct method of use, such as mercury used as the main drug for the treatment of skin cancer, cervical cancer, can only be limited to external use, strictly forbidden to take internally, otherwise mercury poisoning will occur. Some herbs, although mildly toxic, can have serious toxic side effects if used in excessive doses. For example, mucuna pruriens has a lactogenic effect, if its large dose (50 grams) and pig’s feet cooked together, after serving will occur kidney function damage. Another example is white fruit, because it contains a trace of hydrocyanic acid, in excess, there will be fever, vomiting, diarrhea, convulsions, convulsions, limb tonicity, skin bruising, pupils dilated, weak and chaotic pulse, and even coma and other poisoning phenomena. When it is necessary to use some toxic herbs, firstly, caution should be exercised, close observation should be made, and attention should be paid to whether the dose is appropriate, and the former should be slightly longer. Secondly, it can be combined with some drugs to reduce toxicity. For example, the ten jujube pill used for ascites of liver cirrhosis is combined with jujube to moderate Gansui, Daji and Coriander, which are herbs with strong laxative effect, to reduce the effect of toxicity. For some toxic herbs, licorice is often used to moderate the toxicity. It has been proved that licorice sweeteners contained in licorice do have antitoxic effect in pharmacology, confirming the correct conclusion that licorice is “antidote to the poison of all medicines” as recorded in the Compendium of Materia Medica. So, is it safe to use non-toxic Chinese medicine? For example, the legendary panacea, Banlangen, can be used for common diseases such as cold, fever, mumps and laryngitis. Is there no problem with the use of such drugs? Studies have shown that this is not always the case. There are three types of people who should use caution: First, the elderly and infirm should be careful with Banlangen. It is not a panacea, let alone a cure for all diseases. From the taste of the drug, it is a cold product, so it is used to treat the actual heat of the disease, for the elderly and frail, the spleen and stomach cold, long-term use of a large number of people, it will make its body further decline, but also can appear light mouth, fatigue and other symptoms. Secondly, diabetic patients should not take sugary blueberry. It is also not advisable for people with diabetes to take granules containing sugar. Thirdly, allergic people should be prohibited from taking Pancreatic Injection. The majority of allergic reactions are caused by Panax notoginseng injection, manifested as dizziness, shortness of breath, vomiting, panic, rash, sometimes for the whole body erythema multiforme type drug rash, severe cases of blood pressure drop and anaphylactic shock, rescue is not timely will be life-threatening. Allergic to Pancreatic, to avoid using. Recently, the State Food and Drug Administration issued a “notice on the revision of the instructions of the brain Jing injection”, requiring the instructions to increase the “adverse reactions to this product, including anaphylaxis” and other warning words. This adjustment and requirements, experts believe that this is a regular action of the State Food and Drug Administration on the safety of proprietary Chinese medicine standardized management. In addition to awakening the brain Jing injection, but also to toxic side effects, contraindications and precautions described too simply Lei Gong Vine tablets, anti-inflammatory and bile tablets, Lian Biji injection, Xiang Dan injection, safflower injection and other proprietary Chinese medicines have also been proposed to amend the requirements. It is worth noting that some pharmacies sell OTC (over-the-counter) proprietary Chinese medicines, which contain toxic ingredients without drawing attention to them, but also feel that the raw materials of proprietary Chinese medicines are natural plants and animals or minerals, and their safety is higher. In fact, it is not uncommon to see reports of damaging effects on the liver and kidneys, as well as excessive heavy metals such as mercury and lead in some pCms or important tablets. Just because Chinese herbs come from natural sources, their composition is more complex and uncertain, and light and temperature differences in the transportation and storage of Chinese herbal injections can also affect their stability, so the safety of Chinese herbal injections should be given more attention. If the prescription contains toxic Chinese medicines that are prone to adverse reactions, the manufacturer should also revise the instructions as required. At the same time, the varieties of proprietary Chinese medicines containing toxic Chinese medicinal tablets need to revise the instructions, must increase the warning language containing toxic tablets. In addition, pCms can be taken orally is not recommended for intramuscular injection, can be injected intramuscularly is not recommended for static drip.